منابع مشابه
Acquired immunity to malaria.
Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how this protection works. There is no general agreement about the rate of onset of acquired immunity or what constitutes the key determinants of protection; much less is there a consensus regarding the ...
متن کاملMalaria transmission and naturally acquired immunity to PfEMP-1.
Why there are so few gametocytes (the transmission stage of malaria) in the blood of humans infected with Plasmodium spp. is intriguing. This may be due either to reproductive restraint by the parasite or to unidentified gametocyte-specific immune-mediated clearance mechanisms. We propose another mechanism, a cross-stage immunity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP-1)...
متن کاملAcquired immunity and postnatal clinical protection in childhood cerebral malaria.
By analysing data on the age distribution of cerebral malaria among sites of different transmission intensities, we conclude that the most plausible explanation for the epidemiological patterns seen is that (i) cerebral malaria is caused by a distinct set of Plasmodium falciparum antigenic types; (ii) these antigenic types or 'CM strains' are very common and induce strong strain-specific immuni...
متن کاملModeling the development of acquired clinical immunity to Plasmodium falciparum malaria.
Individuals living in regions where malaria is endemic develop an acquired immunity to malaria which enables them to remain asymptomatic while still carrying parasites. Field studies indicate that cumulative exposure to a variety of diverse Plasmodium parasites is required for the transition from symptomatic to asymptomatic malaria. This study used a simulation model of the within-host dynamics...
متن کاملChloroquine Inhibits Protective Immunity to Mouse Malaria
271 Received July 24, 2014; revised and accepted November 5, 2014. Published online December 4, 2014; doi: 10.1620/tjem.234.271. Correspondence: Yaming Cao, Department of Immunology, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang, Liaoning 110001, P.R. China. e-mail: [email protected] Early Treatment with Chloroquine Inhibits the Im...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2009
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00025-08